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Periodontitis lesions are the main source of salivary cytomegalovirus

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Periodontitis lesions are the main source of salivary cytomegalovirus

Auteurs : S. Sahin [Turquie] ; I. Saygun [Turquie] ; A. Kubar [Turquie] ; J. Slots [États-Unis]

Source :

Oral microbiology and immunology [ 0902-0055 ] ; 2009.

RBID : Pascal:09-0278786

Descripteurs français

Pascal (Inist)
- Cytomegalovirus, Virus Epstein Barr, Lésion, Parodontopathie, Salive, Microbiologie, Immunologie, Parodontite, Virose.
Wicri :
- topic : Immunologie.

English descriptors

KwdEn :
- Cytomegalovirus, Epstein Barr virus, Immunology, Lesion, Microbiology, Periodontal disease, Periodontitis, Saliva, Viral disease.

Abstract

Background: Herpesviruses play causal or cooperative roles in childhood infections, tumorigenesis, ulcerogenesis, and periodontitis. Saliva is a common vehicle of herpesvirus horizontal transmission, but the source of salivary herpesviruses remains obscure. To evaluate the significance of periodontal disease in shedding of oral herpesviruses, this study determined the genome-copy counts of human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) in whole saliva of subjects with periodontitis, gingivitis, or no natural teeth. Methods: Whole saliva was collected from 14 periodontitis patients, 15 gingivitis patients and 13 complete denture wearers. The study subjects were systemically healthy and had not received periodontal treatment in the past 3 months. Real-time TaqMan polymerase chain reaction was used to determine the salivary load of HCMV and EBV. Results: Salivary HCMV was detected in seven (50%) periodontitis patients, but not in any gingivitis or edentulous subjects (P < 0.001). Salivary EBV was detected in 11 (79%) periodontitis patients, in five (33%) gingivitis patients, and in seven (54%) edentulous subjects (P = 0.076). Salivary samples showed copy counts of HCMV in the range of 3.3 x 10³-4.2 x 10⁴/ml and of EBV in the range of 3.6 x 10²-1.6 x 10⁹/ml. Conclusions: HCMV and EBV are commonly present in the saliva of periodontitis patients. Periodontitis lesions of systemically healthy subjects seem to constitute the main origin of salivary HCMV, but do not comprise the sole source of salivary EBV.

Affiliations:

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Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cytomegalovirus</term>
<term>Epstein Barr virus</term>
<term>Immunology</term>
<term>Lesion</term>
<term>Microbiology</term>
<term>Periodontal disease</term>
<term>Periodontitis</term>
<term>Saliva</term>
<term>Viral disease</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Cytomegalovirus</term>
<term>Virus Epstein Barr</term>
<term>Lésion</term>
<term>Parodontopathie</term>
<term>Salive</term>
<term>Microbiologie</term>
<term>Immunologie</term>
<term>Parodontite</term>
<term>Virose</term>
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<front><div type="abstract" xml:lang="en">Background: Herpesviruses play causal or cooperative roles in childhood infections, tumorigenesis, ulcerogenesis, and periodontitis. Saliva is a common vehicle of herpesvirus horizontal transmission, but the source of salivary herpesviruses remains obscure. To evaluate the significance of periodontal disease in shedding of oral herpesviruses, this study determined the genome-copy counts of human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) in whole saliva of subjects with periodontitis, gingivitis, or no natural teeth. Methods: Whole saliva was collected from 14 periodontitis patients, 15 gingivitis patients and 13 complete denture wearers. The study subjects were systemically healthy and had not received periodontal treatment in the past 3 months. Real-time TaqMan polymerase chain reaction was used to determine the salivary load of HCMV and EBV. Results: Salivary HCMV was detected in seven (50%) periodontitis patients, but not in any gingivitis or edentulous subjects (P < 0.001). Salivary EBV was detected in 11 (79%) periodontitis patients, in five (33%) gingivitis patients, and in seven (54%) edentulous subjects (P = 0.076). Salivary samples showed copy counts of HCMV in the range of 3.3 x 10<sup>3</sup>
-4.2 x 10<sup>4</sup>
/ml and of EBV in the range of 3.6 x 10<sup>2</sup>
-1.6 x 10<sup>9</sup>
/ml. Conclusions: HCMV and EBV are commonly present in the saliva of periodontitis patients. Periodontitis lesions of systemically healthy subjects seem to constitute the main origin of salivary HCMV, but do not comprise the sole source of salivary EBV.</div>
</front>
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Periodontitis lesions are the main source of salivary cytomegalovirus

Periodontitis lesions are the main source of salivary cytomegalovirus

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri